The preparation and teratogenic properties of pure trypan blue and its common contaminants.

The relationship of chemical structure to teratogenic activity among bisazo dyes: a re-evaluation.

Although the potency of trypan blue as a teratogenic agent in rodents has been known for almost twenty years the mechanism of its action remains obscure. The dye produces a variety of biological effects (see review by Beck & Lloyd, 1966) and most of these have at some time been suggested as possibly relevant to its teratogenicity. The investigation of such correlations would clearly be assisted...

Teratogenic action of the thyroid stimulating hormone and its interaction with trypan blue.

Synthesis of TiO2 nanoparticles in pure 2-hydroxyethylammonium formate room temperature ionic liquid and investigation of its photocatalytic properties

TiO2 nanoparticles were synthesized by modified sol—gel method using pure room temperature ionic liquid(RTIL) 2-hydroxyethylammonium formate as a reaction medium. The structure and morphology of TiO2nanoparticles were characterized with X-ray powder diffraction (XRD), BET surface analysis and scanningelectron microscopy (SEM). TiO2 nanoparticles were synthesized in open and closed vessels. The ...

Teratogenic activity of several closely related disazo dyes on the developing chick embryo.

THEt eratogenic activity of several disazo dyes during rat embryogenesis has been investigated by Wilson (1955). In addition to the marked teratogenicity of trypan blue Wilson also demonstrated that Evans blue was moderately active and that Niagara blue 4B and Niagara sky blue 6B were possibly active. On the other hand, several other closely related disazo dyes such as Congo red and azo blue we...

Trypan blue induced teratogenesis of rat embryos cultivated in vitro.

Trypan blue is known to produce embryonic abnormalities in a wide variety of animals, including rats (Gillman, Gilbert, Gillman & Spence, 1948), mice (Waddington & Carter, 1953; Hamburgh, 1954), amphibians (Waddington & Perry, 1956), chickens (Beaudoin & Wilson, 1958;Stephan & Sutter, 1961), rabbits (Ferm, 1956), and hamsters (Ferm, 1958). Studies on the teratogenic action of this dye have also...